Unsupervised Low Light Image Enhancement Using SNR-Aware Swin Transformer

Image captured under low-light conditions presents unpleasing artifacts, which debilitate the performance of feature extraction for many upstream visual tasks. Low-light image enhancement aims at improving brightness and contrast, and further reducing noise that corrupts the visual quality. Recently, many image restoration methods based on Swin Transformer have been proposed and achieve impressive performance. However, On one hand, trivially employing Swin Transformer for low-light image enhancement would expose some artifacts, including over-exposure, brightness imbalance and noise corruption, etc. On the other hand, it is impractical to capture image pairs of low-light images and corresponding ground-truth, i.e. well-exposed image in same visual scene. In this paper, we propose a dual-branch network based on Swin Transformer, guided by a signal-to-noise ratio prior map which provides the spatial-varying information for low-light image enhancement. Moreover, we leverage unsupervised learning to construct the optimization objective based on Retinex model, to guide the training of proposed network. Experimental results demonstrate that the proposed model is competitive with the baseline models

Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients

<p>Abstract</p> <p>Background</p> <p>Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance.</p> <p>Methods</p> <p>To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4.</p> <p>Results</p> <p>We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global <it>p </it>= 0.0005.</p> <p>Conclusions</p> <p>Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.</p